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Date Added: Wed 16/06/2021

Senior Research Associate, T-Cell Process Development

Cambridge, MA, US
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Job Type: Permanent, FullTime

Job Description

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and have a clinical manufacturing facility in Stevenage, UK. This role is located in Cambridge, Massachusetts.

We are looking for a Senior Research Associate to join the T Cell Process Development team to work on cutting edge TRuC T cell manufacturing process, and to support regulatory filings. You will report to our Senior Scientist, T Cell Process Development and work closely with the Analytical Development group and other teams as needed. This is an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment to support the production and in vitro characterizations of novel autologous and allogeneic TRuC-T cells programs.


  • Perform T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems
  • Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells
  • Collaborate with the Analytical Development group in improving primary T-cells characterization
  • Contribute to the development and production of TRuC™ T-cells for various pipeline programs and in-vivo animal studies
  • Analyze results and document scientific results for IND enabling studies


  • B.S./M.S. degree in immunology, cell biology or similar discipline with 2+ years of experience in biotech and/or Pharma
  • Experience in analytical assay execution and development, particularly cell based toxicity assays is required and flow cytometry, ELISA, PCR is preferred
  • Experience working with lentiviral and transduction of human T cells along with functionally closed systems are highly desirable. If no experience this is an opportunity to learn!
  • Excellent attention to detail and problem-solving skills, ability to analyze and interpret data.
  • Must be a highly effective collaborator with strong written/verbal communication and interpersonal skills

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