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DATE ADDED: Wed 12/06/2019

Oxford Genetics - Scientist Viral Vector Engineering

Oxford, UK

JOB TYPE: Permanent

SALARY: £28000 - £38000/annum plus benefits dependent on experie

Oxford Genetics, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications.

A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford.

We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do - join us and contribute to this exciting journey!

The Scientist - Viral vector engineering will be involved in a range of internal platform development and commercial projects, predominantly focused on Adenoviral and rAAV vector engineering, production, and analysis. The Scientist role is expected to drive and lead specific projects and areas of research from the bench, while providing support and training to Associate Scientists and technicians working in the group, which addresses both viral vector engineering and novel bioproduction methodologies. Oxford Genetics intends to further build its expertise over the next 6-12 months in the Viral Therapeutics field, predominantly around Lentiviral, AAV and Adenoviral vectors. The position will involve extensive interaction with both internal and external stakeholders, and the ability to show commitment to scientific development and innovation are considered essential. Prior experience in adenoviral and/or rAAV vector engineering and production is highly desirable.

• Work closely with internal and external stakeholders to define project goals and deliverables, in line with the planned project objectives
• To line manage and train junior staff in laboratory techniques (as appropriate for level of appointment)
• Support line manager with customer interactions, and in ensuring smooth running of the group
• To adhere strictly to established quality standards, essential for on-going activities
• Drafting and reviewing SOPs
• To author scientific reports in a timely manner with high accuracy and quality
• Promote and suggest implementation of new methods, technologies and processes to ensure best practice
• Carrying out any other duties commensurate with the grading of the position, as required

• MSc in Biology, Biochemistry, Genetics or related field, with >2 years relevant experience or Ph.D with >1 year relevant experience
• Experience working in a commercial/industry environment is preferred but not essential

• Extensive track record of handling a range of adherent and suspension mammalian cell lines
• Good knowledge and experience of viral vector engineering, production and characterisation, with a focus on Adenoviral and rAAV vectors
• Experience with analytical techniques for Adenoviral or rAAV vectors, e.g. TCID50, qPCR, etc.
• Ability to independently analyse, interpret and present scientific data in a clear manner
• Good communication and inter-personal skills
• Strong ability to multi-task under time pressure
• Good attention to details

• Experience in designing, generating and screening libraries (promoters, gRNAs, CDS, etc.)
• Knowledge or experience in Cell engineering/stable cell line development
• Use of robotic liquid handling and automation systems
• Knowledge in process development for viral vector production
• Knowledge or experience in project management

Job type: Permanent, office and laboratory based
Hours: Full time 37.5 hours pw
Salary: £28,000 - £38,000 pa plus benefits dependent on experience

In addition to undertaking the duties above, the post-holder will be expected to fully adhere to the following:

Personal Development:
• To actively participate in their performance review and work towards objectives set.
• To take responsibility for their own professional development ensuring professional standards are maintained and mandatory training is in date.
• To attend training as requested.

Code of Conduct and Quality:
• To uphold the company mission and values.
• To support the company in developing an effective work/life balance for employees that meets the needs of the organisation.
• To adhere to quality processes and procedures and strive for continuous quality improvement.

Equal Opportunities/Diversity:
• To observe the company's Equal Opportunities Policy providing equality of treatment and opportunity to employees, irrespective of sex, sexuality, age, marital status, ethnic origin or disability.

Health Safety:
• To take responsibility for the health safety of themselves and other persons who may be affected by their omissions or actions at work.
• To promote the company Health and Safety Policy and ensure matters are managed in accordance with it.
• To report accidents, incidents and near misses, implementing corrective action where necessary.

Confidentiality and Data Security
• To comply fully with the duties and responsibilities outlined the company handbook regarding confidentiality.
• To comply with the Data Protection Act 2018 and future similar legislation and ensure that all information collected, stored and used is done so in compliance with the Act.
• To preserve the confidentiality of any information in connection with their employment. This obligation shall continue in perpetuity.

25 days Annual Leave plus Bank Holidays, Pension with matched employer contribution to 7% with salary exchange, Health Insurance, Group Life Cover, Glasses Vouchers and a friendly working environment in an exciting and expanding young company.

Simplified Recruitment is a Job Advertising Agency working on behalf of Oxford Genetics Ltd. By applying for this position you are giving us permission to pass your CV and covering letter to a third party in relation to recruitment. A full copy of our privacy policy can be viewed on our website.

Ref: SR(phone number removed)
Role: Oxford Genetics - Scientist Viral Vector Engineering
Job Type: Permanent
Location: Oxford, Oxfordshire,

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