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Date Added: Thu 30/07/2020

Research Associate II Purification Process Development Req# 2026

South San Francisco, California, US
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Job Type: Permanent, FullTime

At Encoded, we are combining the precision of gene regulation with the versatility of gene therapies to create breakthrough treatments for individuals living with severe genetic diseases. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. Encoded Therapeutics is funded by world-class healthcare investors Venrock, Arch Venture Partners, Illumina Ventures, and Matrix Capital Management. For more information, please visit us online at .

This is a unique opportunity to work at the intersection of genomics and therapeutics and participate in the development of a diverse therapeutic pipeline driven by a transformative core technology. The position of Research Associate II will assist the Downstream Purification Process Development group at Encoded Therapeutics. A qualified candidate will be responsible for purification process development and support purification of our lead program at small and pilot scales. The ideal candidate will be hardworking, flexible and able to perform key responsibilities across multiple projects in a fast-paced and dynamic environment.


* Continue to help innovate, optimize and evaluate our scale-up purification process
* Relevant experience in the following purification or separation techniques: Cell culture fluid depth filtration, tangential flow-filtration, column chromatography techniques such as affinity, ion-exchange, multimodal or hydrophobic interaction chromatography
* Experience with AKTA Pure, Avant or Pilot or similar is desired
* Assist in executing in-process assays including PCR, ELISAs or HPLC based assays to support process development of rAAV products and process intermediates

* Understanding of HPLC techniques such as SEC, RP-HPLC, ion-exchange or hydrophobic interaction chromatography is preferred

* Assist in buffer and solution making to support upstream/downstream scale-up activities (including low-endotoxin buffers) and analytical assays
* The employee will help compile, analyze and interpret data, write reports if necessary and present data in team meetings
* Must have a drive to troubleshoot process challenges, learn new and emerging AAV technologies with a strong sense of initiative
* Work in a multi-disciplinarian environment to assist multiple groups in the development and execution of study plans, process procedures, assay development and qualification, writing of SOPs or assist in the tech transfer to CMO or CMC related activities


* B.S in a relevant area of specialization (biochemistry, biochemical engineering, chemical engineering, biological sciences, virology or molecular biology)
* 2+ years of industry and/or academic experience in assay development or in a process development setting
* Strong verbal and written communication skills are essential and effective interpersonal, technical discretion and ability to multitask effectively are strongly desired
* Proficient in Microsoft based Windows programs such as Excel, PowerPoint and Word. Familiarity with Unicorn, Empower, SoftMax Pro is desired

Preferred Qualifications

* M.S. in a relevant area of specialization (biochemistry, biochemical engineering, chemical engineering, biological sciences, virology or molecular biology


* Comprehensive benefits package, including competitive employer premium contributions
* Meaningful stock option grants
* PTO, sick time and holiday pay
* Generous Parental Leave program
* Pre-tax medical and dependent care programs
* LTD, Life and AD&D
* Professional development opportunities
* Team-building events
* Fully stocked kitchen

Encoded Therapeutics, Inc. is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.

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