Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.

We are recruiting a Postdoctoral Fellow to join Roser Vento-Tormo's lab in our Cellular Genomics Programme for a fixed term until 31st July 2028.

About Us:

Endometriosis is a common inflammatory disorder affecting around 10% of women and people with a uterus of reproductive age. It occurs when uterine-like cells grow outside the uterus, leading to chronic, often debilitating pain and, in some cases, infertility. Current treatments rely on hormone-based therapies that manage symptoms rather than provide a cure. These treatments often have significant side effects and are not effective for all patients.

Our research integrates advanced genomics technologies to identify candidate genes and cell types that may enable the development of new treatments. In this role, the Postdoctoral Researcher will lead experimental work in a translational project focused on testing non-hormonal therapeutic targets for endometriosis, using organoids and gene-editing technologies.

What you'll be doing:

In this position, you will be responsible for a project, aimed at developing screening platforms for detection and validation of potential therapeutic targets in organoids and co-cultures of the reproductive system. The project involves using the established CRISPR/Cas9 technology and small molecule screenings on these cells, employing single-cell genomics and functional analyses as key read-outs.

Key publications of the team:

• Marečková, Magda, Luz Garcia-Alonso, Marie Moullet, Valentina Lorenzi, Robert Petryszak, Carmen Sancho-Serra, Agnes Oszlanczi, et al. 2024. "An Integrated Single-Cell Reference Atlas of the Human Endometrium." Nature Genetics 56 (9): #removed#.
  
• Garcia-Alonso, Luz, Louis-François Handfield, Kenny Roberts, Konstantina Nikolakopoulou, Ridma C. Fernando, Lucy Gardner, Benjamin Woodhams, et al. 2021. "Mapping the Temporal and Spatial Dynamics of the Human Endometrium in Vivo and in Vitro." Nature Genetics 53 (12): #removed#.
  
• Arutyunyan A, Roberts K, Troulé K, Wong FCK, Sheridan MA, Kats I, Garcia-Alonso L, Velten B, Hoo R, Ruiz-Morales ER, Sancho-Serra C, Shilts J, Handfield LF, Marconato L, Tuck E, Gardner L, Mazzeo CI, Li Q, Kelava I, Wright GJ, Prigmore E, Teichmann SA, Bayraktar OA, Moffett A, Stegle O, Turco MY, Vento-Tormo R. "Spatial multiomics map of trophoblast development in early pregnancy." Nature. 2023 Apr;616(7955):#removed#.
  
• Garcia-Alonso L, Lorenzi V, Mazzeo CI, Alves-Lopes JP, Roberts K, Sancho-Serra C, Engelbert J, Marečková M, Gruhn WH, Botting RA, Li T, Crespo B, van Dongen S, Kiselev VY, Prigmore E, Herbert M, Moffett A, Chédotal A, Bayraktar OA, Surani A, Haniffa M, Vento-Tormo R. "Single-cell roadmap of human gonadal development." Nature. 2022 Jul;607(7919):#removed#.
  

About You:

You are interested in reproductive health and have experience in cellular and molecular biology. You enjoy both working independently and collaborating with others in a team environment. We welcome your application if you have skills and experience in the following:

• Cell and molecular biology
  
• Cell culture, including organoids, especially on a high throughput scale
  
• Gene editing technology
  

You will be part of a vibrant international Postdoctoral Fellow community at the Sanger Institute with a wide programme of transferable skills training and excellent career development opportunities. For more information about being a Postdoctoral Fellow - please visit: https://youtu.be/1-vxm2nBmFA

Essential Skills:

• PhD in biological sciences (cell biology, molecular biology, biotechnology, reproductive biology), or on track to be awarded your PhD within 6 months of starting the role
  
• A track record of demonstrating research excellence and expertise in your area of research with a publication record and ability to deliver research projects
  
• Knowledge of Cell and molecular biology, cell culture (including organoids) and interpreting transcriptomic data
  
• Ability to analyse and interpret data with strong quantitative/computational skills
  
• Experience with core molecular biology techniques, including sample preparation, RT, qPCR and RNA/DNA extraction
  
• Proven ability to develop and maintain effective working relationships with wide range of persons of differing level, abilities and knowledge
  
• Foster an inclusive culture where all can thrive and diversity is celebrated
  
• Ability to effectively communicate ideas and results and present orally to groups
  
• Commitment to personal development and updating of knowledge and skills
  
• Ability to prioritise, multi-task and work independently
  
• Detailed orientated, strong organisational and problem-solving skills
  
• Ability to test, implement and troubleshoot new techniques and protocols
  
• Flexibility and ability to adapt to changing priorities
  

Other Information:

Salary per annum (dependent upon skills and experience): £38,000-£49,156

Application Process:

Please apply with your CV and a cover letter outlining how you meet the criteria set out above.

Closing Date: 28th September 2025

Hybrid Working at Wellcome Sanger:

We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity and Inclusion:

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That's why we're committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Our Benefits:

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018. The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.